The long-awaited meeting between the two pioneers of Italian-American research that has led to the discovery of its many benefits. Vittorio Unfer and Jhon E. Nestler address the topic on the balance between the two main inositol stereoisomers, myo-inositol and D-chiro-inositol. The importance of the 40: 1 ratio myo- to D-chiro in PCOS treatment.