Authors:
Unfer V.
Abstract
We read with great appreciation the article “Two decades after Rotterdam consensus: a proposed novel evidence-based practical modifications”, authored by Dr. Mohammad Emam, and published in your esteemed journal [1].
As the Experts Group on Inositol in Basic and Clinical Research, and on PCOS (EGOI-PCOS), we express our strong agreement with the key concepts presented in the paper, which reflect a necessary and long-overdue evolution in the diagnostic and pathogenic framework of polycystic ovary syndrome (PCOS).
We wholeheartedly support the author’s proposal to re-center the pathophysiological interpretation of PCOS around insulin resistance [2]. This paradigm shift—from the long-standing emphasis on obesity as a primary causative factor to recognizing it as an amplifier of pre-existing endocrine-metabolic dysfunction—is not only scientifically sound but also clinically transformative [3]. It compels clinicians and researchers to reconsider the true underlying mechanisms of the syndrome and adopt more tailored, effective therapeutic strategies [4].
